For the first time, American scientists have used stem cells to create neuromuscular junctions between human muscle cells and spinal cord cells in the laboratory. The latest research paves the way for scientists to develop "human body chip" systems. In the future, scientists can use these "human body chip" systems to accelerate the pace of medical research and drug testing, and get medical breakthroughs faster, without the need to use traditional methods for years of animal and human trials of drugs.
The "human body chip" system is a model that can reproduce how organs or a series of organs work in the body. In order to obtain a body chip system that can reproduce various functions of the human body, these neuromuscular nodes must be developed. The brain uses these nodes to "communicate" with the muscles in the body and control the body's muscles.
In the latest study, Professor Hermann van den Berg of Brown University in the United States first collected many muscle stem cells from adult volunteers through biopsy methods. Nadine Guo from the University of Central Florida conducted a series of experiments, using different concentrations of cells and different time intervals and other parameters to create the most suitable environment for “happy†combination of muscle cells and spinal cord cells. Neuromuscular junctions.
The study was funded by the National Institute of Neurological Disorders under the National Institutes of Health (NIH). The paper will be published in the December issue of Biomaterials. The leader of the study, James Hickman, a biological engineer at the University of Central Florida, said that he is very optimistic about the future of the study. Traditional animal testing methods are not only slow, expensive, but often fail, hindering the development of new drugs and the emergence of new drugs. process.
The National Institutes of Health, the U.S. Department of Defense Advanced Research Projects Agency, and the U.S. Food and Drug Administration are all accelerating the development of the "human body chip" model. Now, at least $140 million has been invested in this field. The purpose of these research teams is to create systems that contain a variety of interconnected mini-organs that mimic human functions in the way that they actually use. Scientists will be able to use these systems to test their effects on human cells before the drug is safely and ethically tested in humans. This technique is expected to be more efficient than testing on rats and other animals.
In addition to being used to develop human body chip models, neuromuscular junctions are also very important research tools in themselves. They also play an important role in amyotrophic lateral sclerosis, spinal cord injury, and other degenerative diseases. Scientists say that the newest technology can be used to test new drugs or other therapies to treat these diseases before a broader chip-based model is developed.
The "human body chip" system is a model that can reproduce how organs or a series of organs work in the body. In order to obtain a body chip system that can reproduce various functions of the human body, these neuromuscular nodes must be developed. The brain uses these nodes to "communicate" with the muscles in the body and control the body's muscles.
In the latest study, Professor Hermann van den Berg of Brown University in the United States first collected many muscle stem cells from adult volunteers through biopsy methods. Nadine Guo from the University of Central Florida conducted a series of experiments, using different concentrations of cells and different time intervals and other parameters to create the most suitable environment for “happy†combination of muscle cells and spinal cord cells. Neuromuscular junctions.
The study was funded by the National Institute of Neurological Disorders under the National Institutes of Health (NIH). The paper will be published in the December issue of Biomaterials. The leader of the study, James Hickman, a biological engineer at the University of Central Florida, said that he is very optimistic about the future of the study. Traditional animal testing methods are not only slow, expensive, but often fail, hindering the development of new drugs and the emergence of new drugs. process.
The National Institutes of Health, the U.S. Department of Defense Advanced Research Projects Agency, and the U.S. Food and Drug Administration are all accelerating the development of the "human body chip" model. Now, at least $140 million has been invested in this field. The purpose of these research teams is to create systems that contain a variety of interconnected mini-organs that mimic human functions in the way that they actually use. Scientists will be able to use these systems to test their effects on human cells before the drug is safely and ethically tested in humans. This technique is expected to be more efficient than testing on rats and other animals.
In addition to being used to develop human body chip models, neuromuscular junctions are also very important research tools in themselves. They also play an important role in amyotrophic lateral sclerosis, spinal cord injury, and other degenerative diseases. Scientists say that the newest technology can be used to test new drugs or other therapies to treat these diseases before a broader chip-based model is developed.
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